GDF6 antibody (C-Term)

Catalog No. ABIN499881

The Rabbit Polyclonal anti-GDF6 antibody (ABIN499881) specifically detects GDF6 in WB and EIA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for GDF6 antibody (C-Term) (ABIN499881)

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDF6 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-GDF6 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to GDF6.

Purification: Affinity chromatography purified via peptide column

Immunogen: GDF6 antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human GDF6.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for GDF6

Target: GDF6 (Growth Differentiation Factor 6 (GDF6))

Alternative Name: BMP13 / GDF6

Background: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.Synonyms: Bone Morphogenetic Protein 13, CDMP2, Cartilage Derived Morphogenetic Protein 2, GDF-16, GDF-6, GDF16

Gene ID: 392255

NCBI Accession: NP_001001557

UniProt: Q6KF10