ILP-2 antibody

Catalog No. ABIN500020

This Rabbit Polyclonal antibody specifically detects ILP-2 in WB, IF and EIA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for ILP-2 antibody (ABIN500020)

Target: ILP-2 (BIRC8) (Baculoviral IAP Repeat-Containing 8 (BIRC8))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ILP-2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-ILP-2 Antibody

Specificity: ILP-2 antibody was raised with against a synthetic peptide corresponding to amino acids near the amino terminus of human ILP-2.

Purification: Affinity chromatography purified via peptide column

Immunogen: Human ILP-2 Peptide

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1 to 2 μg/mL. Human HepG2 or MOLT4 cell lysate can be used as a positivecontrol and a band at approximately 33 kDa can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for ILP-2

Target: ILP-2 (BIRC8) (Baculoviral IAP Repeat-Containing 8 (BIRC8))

Alternative Name: BIRC8 / ILP2

Background: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.Synonyms: Baculoviral IAP repeat-containing protein 8, IAP-like protein 2, ILP-2, Inhibitor of apoptosis-like protein 2, Testis-specific inhibitor of apoptosis

Gene ID: 112401

NCBI Accession: NP_203127

UniProt: Q96P09