LRRC1 antibody (C-Term)

Catalog No. ABIN500136

Product Details anti-LRRC1 Antibody

Target: LRRC1 (Leucine Rich Repeat Containing 1 (LRRC1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects LRRC1.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogen: Lano antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human Lano.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 -2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for LRRC1

Target: LRRC1 (Leucine Rich Repeat Containing 1 (LRRC1))

Alternative Name: LRRC1 (LRRC1 Products)

Synonyms: LRRC1 antibody, LANO antibody, dJ523E19.1 antibody, A430093J20Rik antibody, AU016091 antibody, D030059I21 antibody, mKIAA4018 antibody, leucine rich repeat containing 1 antibody, Lrrc1 antibody, LRRC1 antibody

Background: Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble (1). The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells (2). Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions (1,3). It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues (4,5).Synonyms: LANO, LANO adapter protein, LAP and no PDZ protein, LRRC1, Leucine-rich repeat-containing protein 1

Gene ID: 55227

UniProt: Q9BTT6