FAIM2 antibody (N-Term)

Catalog No. ABIN500148

The Rabbit Polyclonal anti-FAIM2 antibody (ABIN500148) specifically detects FAIM2 in WB, IHC (p) and EIA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for FAIM2 antibody (N-Term) (ABIN500148)

Target: FAIM2 (Fas Apoptotic Inhibitory Molecule 2 (FAIM2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAIM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-FAIM2 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects FAIM2.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: LFG antibody was raised against a 16 amino acid peptide from near the amino terminus of human LFG.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for FAIM2

Target: FAIM2 (Fas Apoptotic Inhibitory Molecule 2 (FAIM2))

Alternative Name: FAIM2

Background: Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. LFG is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-? death signal. In this respect, LFG is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. LFG, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. LFG is widely distributed, but highly expressed in the hippocampus and other neural tissues. LFG was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.Synonyms: Fas apoptotic inhibitory molecule 2, KIAA0950, LFG, Protein lifeguard, TMBIM2, Transmembrane BAX inhibitor motif-containing protein 2

Gene ID: 23017

UniProt: Q9BWQ8