MACC1 antibody (Center)

Catalog No. ABIN500214

The Rabbit Polyclonal anti-MACC1 antibody (ABIN500214) specifically detects MACC1 in WB, IHC (p) and EIA. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for MACC1 antibody (Center) (ABIN500214)

Target: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MACC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-MACC1 Antibody

Binding Specificity: Center

Specificity: This antibody detects MACC1 at center.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: MACC1 antibody was raised against a 17 amino acid peptide near the center of human MACC1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for MACC1

Target: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Alternative Name: MACC1

Background: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.Synonyms: Metastasis-associated in colon cancer protein 1

Gene ID: 346389

UniProt: Q6ZN28