MOAP1 antibody (Center)

Catalog No. ABIN500228

The Rabbit Polyclonal anti-MOAP1 antibody has been validated for WB and EIA. It is suitable to detect MOAP1 in samples from Human and Mouse.

Quick Overview for MOAP1 antibody (Center) (ABIN500228)

Target: MOAP1 (Modulator of Apoptosis 1 (MOAP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MOAP1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-MOAP1 Antibody

Binding Specificity: Center

Specificity: This antibody detects Modulator of apoptosis 1 at enter.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogen: MAP-1 antibody was raised against a 15 amino acid peptide from near the center of human MAP-1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for MOAP1

Target: MOAP1 (Modulator of Apoptosis 1 (MOAP1))

Alternative Name: MOAP1

Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo (4). It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis (5).Synonyms: MAP-1, MAP1, Modulator of apoptosis 1

Gene ID: 64112

NCBI Accession: NP_071434

UniProt: Q96BY2

Pathways: Positive Regulation of Endopeptidase Activity