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MOAP1 antibody (Modulator of Apoptosis 1) (Center) Primary Antibody

MOAP1 Reactivity: Human, Mouse EIA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500228
$598.40
Plus shipping costs $45.00
0.1 mg
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Available
  • Target
    MOAP1
    Binding Specificity
    • 8
    • 7
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 34
    • 7
    • 4
    Human, Mouse
    Host
    • 31
    • 5
    Rabbit
    Clonality
    • 33
    • 3
    Polyclonal
    Conjugate
    • 24
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This MOAP1 antibody is un-conjugated
    Application
    • 33
    • 19
    • 3
    • 3
    • 1
    • 1
    Enzyme Immunoassay (EIA), Western Blotting (WB)
    Specificity
    This antibody detects Modulator of apoptosis 1 at enter.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse
    Purification
    Peptide affinity chromatography
    Immunogen
    MAP-1 antibody was raised against a 15 amino acid peptide from near the center of human MAP-1.
    Isotype
    IgG
  • Application Notes
    ELISA. Western blot: 1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    MOAP1
    Alternative Name
    MOAP1 (MOAP1 Antibody Abstract)
    Synonyms
    MOAP1, MAP-1, PNMA4, AA987038, Map-1, Pnma4, modulator of apoptosis 1, modulator of apoptosis 1 S homeolog, MOAP1, moap1.S, Moap1
    Background
    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo (4). It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis (5).Synonyms: MAP-1, MAP1, Modulator of apoptosis 1
    Gene ID
    64112
    NCBI Accession
    NP_071434
    UniProt
    Q96BY2
    Pathways
    Positive Regulation of Endopeptidase Activity
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