MATN1 antibody (N-Term)

Catalog No. ABIN500240

The Rabbit Polyclonal anti-MATN1 antibody has been validated for WB and EIA. It is suitable to detect MATN1 in samples from Human, Mouse and Rat.

Quick Overview for MATN1 antibody (N-Term) (ABIN500240)

Target: MATN1 (Matrilin 1, Cartilage Matrix Protein (MATN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MATN1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-MATN1 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects MATN1 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: MATN1 antibody was raised against a 12 amino acid peptide from near the amino terminus of human MATN1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for MATN1

Target: MATN1 (Matrilin 1, Cartilage Matrix Protein (MATN1))

Alternative Name: Matrilin-1

Background: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN1 is composed of two Willebrand Factor A (vWFA) domains separated by one EGF-like domain, whereas MATN3 is composed of a single N-terminal vWFA domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that the MATN1 promoter region was associated with both susceptibility and disease progression in Adolescent idiopathic scoliosis.Synonyms: CMP, CRTM, Cartilage matrix protein, MATN1

Gene ID: 4146

NCBI Accession: NP_002370

UniProt: P21941