CUL9 antibody (C-Term)

Catalog No. ABIN500449

This Rabbit Polyclonal antibody specifically detects CUL9 in WB, IF and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for CUL9 antibody (C-Term) (ABIN500449)

Target: CUL9 (Cullin 9 (CUL9))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CUL9 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-CUL9 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects Cullin-9.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogen: PARC antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human PARC.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot. Immuncytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for CUL9

Target: CUL9 (Cullin 9 (CUL9))

Alternative Name: Cullin-9

Background: The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.Synonyms: CUL-9, H7AP1, KIAA0708, PARC, UbcH7-associated protein 1, p53-associated parkin-like cytoplasmic protein

Gene ID: 23113

NCBI Accession: NP_055904

UniProt: Q8IWT3