Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (N-Term) antibody

Details for Product No. ABIN500493
Antigen
Epitope
N-Term
9
4
2
2
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
46
28
27
4
4
4
4
4
3
2
2
2
1
Host
Rabbit
43
3
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
30
14
13
10
6
2
2
2
1
1
1
Options
Immunogen PICALM antibody was raised against a 15 amino acid peptide from near the amino terminus of human PICALM.
Isotype IgG
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Peptide affinity chromatography
Antigen
Alternative Name PICALM (PICALM Antibody Abstract)
Background PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).Synonyms: CALM, Clathrin assembly lymphoid myeloid leukemia protein, Phosphatidylinositol-binding clathrin assembly protein
Gene ID 8301
NCBI Accession NP_009097
UniProt Q13492
Pathways Synaptic Membrane
Application Notes ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Image no. 1 for anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (N-Term) antibody (ABIN500493) Western blot analysis of PICALM in EL4 cell lysate with this product at 1 μg/ml in (A...