RANBP10 antibody (Center)

Catalog No. ABIN500565

The Rabbit Polyclonal anti-RANBP10 antibody (ABIN500565) specifically detects RANBP10 in WB, IHC (p) and EIA. The antibody is reactive with Human samples.

Quick Overview for RANBP10 antibody (Center) (ABIN500565)

Target: RANBP10 (RAN Binding Protein 10 (RANBP10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RANBP10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-RANBP10 Antibody

Binding Specificity: Center

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogen: RANBP10 antibody was raised against a 15 amino acid peptide near the center of human RANBP10.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RANBP10

Target: RANBP10 (RAN Binding Protein 10 (RANBP10))

Alternative Name: RANBP10

Background: The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.Synonyms: KIAA1464, Ran-binding protein 10

Gene ID: 57610

UniProt: Q6VN20