LMO4 antibody (AA 65-165) (AbBy Fluor® 750)

Catalog No. ABIN5006238

This Rabbit Polyclonal antibody specifically detects LMO4 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for LMO4 antibody (AA 65-165) (AbBy Fluor® 750) (ABIN5006238)

Target: LMO4 (LIM Domain Only 4 (LMO4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMO4 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-LMO4 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 65-165

Predicted Reactivity: Human,Mouse,Rat,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LMO4

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LMO4

Target: LMO4 (LIM Domain Only 4 (LMO4))

Alternative Name: LMO4

Background:

Synonyms: LMO 4, Breast tumor autoantigen, LIM domain only 4, LIM domain only protein 4, LIM domain transcription factor LMO 4, LIM domain transcription factor LMO4, LMO-4, LMO4, LMO4_HUMAN.

Background: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain (1). The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation (2). LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons (3). LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI) (4). NLI, known also as CLIM-1, and the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins (5). LMO2 and the related protein LMO4 are expressed in thymic precursor cells (6). LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors (7).

Gene ID: 8543

Pathways: Tube Formation