MYLK antibody (AA 651-750) (AbBy Fluor® 680)

Catalog No. ABIN5006909

This anti-MYLK antibody is a Rabbit Polyclonal antibody detecting MYLK in IF (cc) and IF (p). Suitable for Rat.

Quick Overview for MYLK antibody (AA 651-750) (AbBy Fluor® 680) (ABIN5006909)

Target: MYLK (Myosin Light Chain Kinase (MYLK))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYLK antibody is conjugated to AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-MYLK Antibody (AbBy Fluor® 680)

Binding Specificity: AA 651-750

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MLCK

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MYLK

Target: MYLK (Myosin Light Chain Kinase (MYLK))

Alternative Name: MLCK

Background:

Synonyms: KRP, AAT7, MLCK, MLCK1, MYLK1, s mMLCK, MLCK108, MLCK210, MSTP083, Myosin light chain kinase, smooth muscle, Kinase-related protein, Telokin, MYLK

Background: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]

Gene ID: 4638

UniProt: Q15746