CBFA2T2 antibody (AA 321-420) (AbBy Fluor® 680)

Catalog No. ABIN5007098

Product Details anti-CBFA2T2 Antibody (AbBy Fluor® 680)

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Binding Specificity: AA 321-420

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBFA2T2 antibody is conjugated to AbBy Fluor® 680

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MTGR1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CBFA2T2

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Alternative Name: MTGR1 (CBFA2T2 Products)

Background:

Synonyms: AML1 MTG8, CBFA2T2, Core binding factor runt domain alpha subunit 2 translocated to 2, EHT, ETO homolog on chromosome 20, ETO homologous on chromosome 20, MTG 8 like protein, MTG 8 related protein 1, MTG8 like protein, MTG8 related protein 1, MTG8-like protein, MTG8-related protein 1, MTG8R_HUMAN, MTGR 1, Myeloid translocation gene related protein 1, Myeloid translocation related protein 1, Myeloid translocation-related protein 1, p85, Protein CBFA2T2, ZMYND 3, ZMYND3.

Background: May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8,21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.Tissue specificity:Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.

Gene ID: 9139