CBFA2T2 antibody (AA 325-604)

Catalog No. ABIN6137998

Product Details anti-CBFA2T2 Antibody

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Binding Specificity: AA 325-604

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBFA2T2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: GLNGGYQDEL VDHRLTEREW ADEWKHLDHA LNCIMEMVEK TRRSMAVLRR CQESDREELN YWKRRYNENT ELRKTGTELV SRQHSPGSAD SLSNDSQREF NSRPGTGYVP VEFWKKTEEA VNKVKIQAMS EVQKAVAEAE QKAFEVIATE RARMEQTIAD VKRQAAEDAF LVINEQEEST ENCWNCGRKA SETCSGCNIA RYCGSFCQHK DWERHHRLCG QNLHGQSPHG QGRPLLPVGR GSSARSADCS VPSPALDKTS ATTSRSSTPA SVTAIDTNGL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 325-604 of human CBFA2T2 (NP_005084.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CBFA2T2

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Alternative Name: CBFA2T2 (CBFA2T2 Products)

Synonyms: MTGR1 antibody, A430091M07 antibody, C330013D05Rik antibody, Cbfa2t2h antibody, EHT antibody, ZMYND3 antibody, p85 antibody, XETOR antibody, cbfa2t2-a antibody, CBFA2/RUNX1 translocation partner 2 antibody, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) antibody, CBFA2/RUNX1 translocation partner 2 L homeolog antibody, Cbfa2t2 antibody, CBFA2T2 antibody, cbfa2t2.L antibody

Background: In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.,CBFA2T2,EHT,MTGR1,ZMYND3,p85,CBFA2T2

Molecular Weight: 28 kDa/63 kDa/65 kDa/67 kDa

Gene ID: 9139

UniProt: O43439