CBFA2T2 antibody (AA 325-604)

Catalog No. ABIN7165192

Product Details anti-CBFA2T2 Antibody

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Binding Specificity: AA 325-604

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBFA2T2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Protein CBFA2T2 protein (325-604AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CBFA2T2

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Alternative Name: CBFA2T2 (CBFA2T2 Products)

Synonyms: MTGR1 antibody, A430091M07 antibody, C330013D05Rik antibody, Cbfa2t2h antibody, EHT antibody, ZMYND3 antibody, p85 antibody, XETOR antibody, cbfa2t2-a antibody, CBFA2/RUNX1 translocation partner 2 antibody, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) antibody, CBFA2/RUNX1 translocation partner 2 L homeolog antibody, Cbfa2t2 antibody, CBFA2T2 antibody, cbfa2t2.L antibody

Background:

Background: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8,21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.

Aliases: AML1 MTG8 antibody, cbfa2t2 antibody, Core binding factor runt domain alpha subunit 2 translocated to 2 antibody, core-binding factor, runt domain, alpha subunit 2 antibody, DKFZp313F2116 antibody, EHT antibody, ETO homolog on chromosome 20 antibody, ETO homologous on chromosome 20 antibody, MTG 8 like protein antibody, MTG 8 related protein 1 antibody, MTG8 like protein antibody, MTG8 related protein 1 antibody, MTG8-like protein antibody, MTG8-related protein 1 antibody, MTG8R_HUMAN antibody, MTGR 1 antibody, Myeloid translocation gene related protein 1 antibody, Myeloid translocation related protein 1 antibody, Myeloid translocation-related protein 1 antibody, p85 antibody, Protein CBFA2T2 antibody, ZMYND 3 antibody, ZMYND3 antibody

UniProt: O43439