SIPA1L3 antibody (N-Term)

Catalog No. ABIN500720

Product Details anti-SIPA1L3 Antibody

Target: SIPA1L3 (Signal-Induced Proliferation-Associated 1 Like 3 (SIPA1L3))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIPA1L3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: SIPA1L3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human SIPA1L3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for SIPA1L3

Target: SIPA1L3 (Signal-Induced Proliferation-Associated 1 Like 3 (SIPA1L3))

Alternative Name: SIPA1L3 (SIPA1L3 Products)

Synonyms: SPAL3 antibody, 2610511M17Rik antibody, signal induced proliferation associated 1 like 3 antibody, signal-induced proliferation-associated 1 like 3 antibody, SIPA1L3 antibody, sipa1l3 antibody, Sipa1l3 antibody

Background: Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice (3) and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.Synonyms: KIAA0545, SPA-1-like protein 3, SPAL3, Signal-induced proliferation-associated 1-like protein 3

Gene ID: 23094

NCBI Accession: NP_055888

UniProt: O60292