Reticulon 4 antibody (AA 301-400) (AbBy Fluor® 750)

Catalog No. ABIN5007767

This anti-Reticulon 4 antibody is a Rabbit Polyclonal antibody detecting Reticulon 4 in WB, IF (cc), IF (p) and FACS. Suitable for Human and Rat.

Quick Overview for Reticulon 4 antibody (AA 301-400) (AbBy Fluor® 750) (ABIN5007767)

Target: Reticulon 4 (RTN4)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Reticulon 4 antibody is conjugated to AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS)

Product Details anti-Reticulon 4 Antibody (AbBy Fluor® 750)

Binding Specificity: AA 301-400

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse RTN4 protein

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Reticulon 4

Target: Reticulon 4 (RTN4)

Alternative Name: Nogo-A

Background:

Synonyms: ASY, NgA, NOGO, NSP-CL, Nogo-A, Nogo-B, Nogo-C, AA407876, AA409940, AA960376, mKIAA0886, mKIAA4153, 1110020G17Rik, C130026I10Rik, Reticulon-4, Neurite outgrowth inhibitor, Nogo protein, Rtn4, Kiaa0886

Background: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.

Gene ID: 68585

UniProt: Q99P72

Pathways: Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome