ST3GAL6 antibody (C-Term)

Catalog No. ABIN500813

The Rabbit Polyclonal anti-ST3GAL6 antibody is suitable to detect ST3GAL6 in samples from Human, Mouse and Rat. It has been validated for WB, EIA and IF.

Quick Overview for ST3GAL6 antibody (C-Term) (ABIN500813)

Target: ST3GAL6 (ST3 beta-Galactoside alpha-2,3-Sialyltransferase 6 (ST3GAL6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ST3GAL6 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Product Details anti-ST3GAL6 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects ST3GAL6.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse and Rat

Purification: Peptide Affinity Chromatography

Immunogen: ST3gal6 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of Human ST3gal6.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ST3GAL6

Target: ST3GAL6 (ST3 beta-Galactoside alpha-2,3-Sialyltransferase 6 (ST3GAL6))

Alternative Name: ST3GAL6

Background: Sialyltransferases catalyze the transfer of sialic acid from cytidine 5-prime monophospho-N-acetylneuraminic acid (CMP-NeuAc) to terminal positions of glycoprotein and glycolipid carbohydrate groups. Terminal NeuAc residues are key determinants of carbohydrate structures, such as the sialyl-Lewis X determinants, and are widely distributed in many cell types. However, cancer cells often express more heavily sialylated glycans on their cell surface and this feature sometimes correlates with invasiveness. In contrast, expression of ST3gal6, a member of the sialyltransferase family that sialylates type II lactosamine structures on glycoproteins and glycolipids, was found to be significantly decreased by hypermethylation of the gene in gastrointestinal cancer. At least three isoforms of ST3gal6 are known to exist.Synonyms: 3-sialyltransferase, 3-sialyltransferase VI, CMP-NeuAc:beta-galactoside alpha-2, SIAT10, ST3Gal VI, ST3GalVI, Sialyltransferase 10, Type 2 lactosamine alpha-2

Gene ID: 10402

NCBI Accession: NP_006091

Pathways: Glycosaminoglycan Metabolic Process