TLR3 antibody (N-Term)

Catalog No. ABIN500950

This Rabbit Polyclonal antibody specifically detects TLR3 in WB, IF and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for TLR3 antibody (N-Term) (ABIN500950)

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-TLR3 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects CD283 / TLR3 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Ion exchange chromatography

Immunogen: TLR3 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR3.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 to 2 μg/mL. K562 cell lysate can be used as positive control. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Alternative Name: CD283 / TLR3

Background: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection (4). Recently it has been shown to recognize viruses such as Influenza A (5) and West Nile Virus and can mediate entry of at least West Nile Virus (6).Synonyms: Toll-like receptor 3

Gene ID: 7098

UniProt: O15455

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades