Ectodysplasin A2 Receptor antibody

Catalog No. ABIN501133

This Rabbit Polyclonal antibody specifically detects Ectodysplasin A2 Receptor in WB, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for Ectodysplasin A2 Receptor antibody (ABIN501133)

Target: Ectodysplasin A2 Receptor (EDA2R)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ectodysplasin A2 Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-Ectodysplasin A2 Receptor Antibody

Specificity: This antibody detects EDA2R / TNFRSF27.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affiinity chromatography

Immunogen: XEDAR antibody was raised against recombinant human XEDAR.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistrry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for Ectodysplasin A2 Receptor

Target: Ectodysplasin A2 Receptor (EDA2R)

Alternative Name: EDA2R / TNFRSF27

Background: X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2) (1). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways (2). Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis (3). The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment (3).Synonyms: EDA-A2 receptor, Tumor necrosis factor receptor superfamily member 27, UNQ2448/PRO5727/PRO34080, X-linked ectodysplasin-A2 receptor, XEDAR

Gene ID: 60401