TNIK antibody (pSer764) (AbBy Fluor® 750)

Catalog No. ABIN5011786

The Rabbit Polyclonal anti-TNIK antibody has been validated for IF (p) and IF (cc). It is suitable to detect TNIK in samples from Mouse and Rat.

Quick Overview for TNIK antibody (pSer764) (AbBy Fluor® 750) (ABIN5011786)

Target: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNIK antibody is conjugated to AbBy Fluor® 750

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-TNIK Antibody (AbBy Fluor® 750)

Binding Specificity: pSer764

Specificity: Phosphorylation site corresponds to Ser735 in mouse

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human TNIK around the phosphorylation site of Ser764

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TNIK

Target: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Alternative Name: TNIK

Background:

Synonyms: TRAF2 and NCK-interacting protein kinase, TNIK, KIAA0551

Background: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Gene ID: 23043

UniProt: Q9UKE5