PF4 antibody

Catalog No. ABIN5026898

This Chicken Polyclonal antibody specifically detects PF4 in WB, IHC, ELISA and Aggl. It exhibits reactivity toward Mammalian.

Quick Overview for PF4 antibody (ABIN5026898)

Target: PF4 (Platelet Factor 4 (PF4))

Reactivity: Mammalian

Host: Chicken

Clonality: Polyclonal

Conjugate: This PF4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Agglutination (Aggl)

Product Details anti-PF4 Antibody

Characteristics: IgY-antibody

Purification: Precipitation with ammoniumsulfate , dialyse and fitration

Immunogen: raw, native protein

Isotype: IgY

Application Details

Application Notes: Perform a chessboard titation before the first application

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, 0.1 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Target Details for PF4

Target: PF4 (Platelet Factor 4 (PF4))

Alternative Name: Platelet-factor 4

Background: Platelet-Factor 4 (PF4) complex is the antigen in heparin-induced thrombocytopenia (HIT), an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. Its autoantibodies have also been found in patients with thrombosis with similar HIT although they have received no prior administration of heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. It is usually found in a complex with proteoglycan.