CLEC4E antibody

Catalog No. ABIN5026978

The Mouse Monoclonal anti-CLEC4E antibody is suitable to detect CLEC4E in samples from Human. It has been validated for WB.

Quick Overview for CLEC4E antibody (ABIN5026978)

Target: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CLEC4E antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ABM42C6

Product Details anti-CLEC4E Antibody

Purification: Protein G Chromatography

Immunogen: A full length human CLEC4E protein was used as the immunogen for this antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for CLEC4E

Target: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Alternative Name: CLEC4E

Background: CLEC4E (C-type lectin domain family 4, member E), also called as Mincle, is a type II transmembrane C-type lectin receptor that specifically binds to the cord factor TDM (trehalose-6,6-dimycolate), a unique glycolipid of mycobacterial cell-surface components, and activates immune cells to confer adjuvant activity. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. CLEC4E is mainly expressed in myeloid cells, such as macrophages and neutrophils and possesses a single carbohydrate-recognition domain (CRD) in the extracellular region. It is associated with FcRgamma chain, an immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor, and acts as an activating receptor that senses damaged cells. CLEC4E is also a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPbeta) and may play a role in inflammation.

Molecular Weight: 25 kDa

Gene ID: 26253

UniProt: Q9ULY5