BCL6 antibody (AA 200-401)

Catalog No. ABIN5027051

This anti-BCL6 antibody is a Mouse Monoclonal antibody detecting BCL6 in WB. Suitable for Human.

Quick Overview for BCL6 antibody (AA 200-401) (ABIN5027051)

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCL6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ABM44G9

Product Details anti-BCL6 Antibody

Binding Specificity: AA 200-401

Purification: Protein G Chromatography

Immunogen: A partial length recombinant BCL-6 protein (amino acids 200-401) was used as the immunogen for this antibody.

Isotype: IgG2b kappa

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Alternative Name: BCL-6

Background: BCL6 (B-cell lymphoma 6) is a 95 kDa zinc finger transcription factor and contains an N-terminal POZ domain. BCL6 is a transcriptional repressor and a master regulator of the germinal center (GC) B cell phenotype controlling its development and growth. BCL-6 modulates IL-4, BCR, and CD40L signals for normal B cell development. Altered BCL6 protein expression is implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL), the most common lymphoma in adults. BCL6 suppresses the expression of p53 (also known as tp53) tumor suppressor gene and modulates DNA damage-induced apoptotic responses in GC B cells.

Molecular Weight: 72 kDa

Gene ID: 604

UniProt: P41182

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus