T-Box 1 antibody (AA 200-410)

Catalog No. ABIN5027059

Product Details anti-T-Box 1 Antibody

Target: T-Box 1 (TBX1)

Binding Specificity: AA 200-410

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant Brachyury protein (amino acids 200-410) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for T-Box 1

Target: T-Box 1 (TBX1)

Alternative Name: Brachyury (TBX1 Products)

Background: Brachyury is a transcription factor encoded by T, a member of the T-box gene family, and required for posterior mesoderm formation and differentiation as well as for notochord development. It is expressed in all nascent mesoderm, in the embryo. Along with embryonic differentiation, it is downregulated, restricted into the notochord and the tail bud, and then lost, when notochordal cells are replaced by bone in the vertebral bodies and by the nucleus pulposus in the intervertebral discs. In the adult, brachyury expression has been found in chordoma, a malignant tumor which recapitulates notochord and derives from small collections of notochordal cells which may persist into the adult life.

Molecular Weight: 55 kDa

Gene ID: 6862

UniProt: O15178

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation