DLL3 antibody (AA 62-286)

Catalog No. ABIN5027148

This Rabbit Polyclonal antibody specifically detects DLL3 in WB. It exhibits reactivity toward Human.

Quick Overview for DLL3 antibody (AA 62-286) (ABIN5027148)

Target: DLL3 (delta Like Protein 3 (DLL3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLL3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DLL3 Antibody

Binding Specificity: AA 62-286

Purification: Protein A Chromatography

Immunogen: A partial length recombinant Delta like 3 protein (amino acids 62-286) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for DLL3

Target: DLL3 (delta Like Protein 3 (DLL3))

Alternative Name: Delta like 3

Background: Delta like 3 (DLL3) is a member of Delta/Serrate/Lag2 (DSL) ligands for Notch receptors and plays a role in Notch signaling. Out of Five DSL ligands, DLL3 is the most structurally divergent DSL ligand. DLL3 is expressed throughout the presomitic mesoderm and is localized to the rostral somatic compartments. Homozygous disruptions of Notch1 and DLL3 result in severe abnormalities in somitogenesis. Mutations in the human DLL3 homolog cause recessive skeletal abnormalities in spondylocostal dysostosis with a consistent pattern of abnormal segmentation.

Molecular Weight: 65 kDa

Gene ID: 10683

UniProt: Q9NYJ7

Pathways: Notch Signaling