DLL4 antibody (AA 423-650)

Catalog No. ABIN5027156

This anti-DLL4 antibody is a Rabbit Polyclonal antibody detecting DLL4 in WB. Suitable for Human.

Quick Overview for DLL4 antibody (AA 423-650) (ABIN5027156)

Target: DLL4 (delta-Like 4 (DLL4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLL4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DLL4 Antibody

Binding Specificity: AA 423-650

Purification: Protein A Chromatography

Immunogen: A partial length recombinant DLL4 protein (amino acids 423-650) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for DLL4

Target: DLL4 (delta-Like 4 (DLL4))

Alternative Name: DLL4

Background: Dll4 (Delta-like 4), a membrane-bound Notch ligand, plays a fundamental role in vascular development and angiogenesis. It is highly expressed in capillary endothelial tip cells and is involved in suppressing neighboring stalk cells to become tip cells during angiogenesis. Dll4-Notch signaling is mediated either by direct cell-cell contact or by Dll4-containing exosomes from a distance. DLL4 signaling is extensively critical for tumor angiogenesis. Blockage of DLL4 signaling inhibits tumor growth by deregulating angiogenesis and promoting non productive angiogenesis. Additionally, DLL4 has been shown to help regulate the cellular actions of VEGF.

Molecular Weight: 75 kDa

Gene ID: 54567

UniProt: Q9NR61

Pathways: Notch Signaling