FURIN antibody (AA 602-791)

Catalog No. ABIN5027210

This anti-FURIN antibody is a Rabbit Polyclonal antibody detecting FURIN in WB. Suitable for Human.

Quick Overview for FURIN antibody (AA 602-791) (ABIN5027210)

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FURIN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FURIN Antibody

Binding Specificity: AA 602-791

Purification: Protein A Chromatography

Immunogen: A partial length recombinant Furin protein (amino acids 602-791) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for FURIN

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Alternative Name: Furin

Background: Furin is a member of the PCs family (Pro-Hormone/Pro-Protein Convertase) of subtilisin-like endoproteinases. Furin along with PCs are intensively investigated as pharmacological targets for the treatment of many diseases, e.g., atherosclerosis, hypercholesterolaemia, and cancer, as well as viral and bacterial infections. Furin has been implicated in processing the Env (Envelope) proteins of human endogenous retroviruses, syncytins, the only possible fusogens known to be involved in placenta syncytialization, and therefore may participate in syncytin-mediated cell fusion in cells of both trophoblast and non-trophoblast lineages. Furin catalyzes proteolytic maturation of a diverse repertoire of growth factors, receptors, and enzyme precursors within multiple secretory pathway compartments. Proteolysis by furin is highly specific and occurs at C-terminal to a multibasic recognition motive. Furin is highly expressed in EVTs (Extravillous CTBs) and that furin function is required for trophoblast cell invasion into the maternal endometrium.

Molecular Weight: 97 kDa

Gene ID: 5045

UniProt: P09958

Pathways: Notch Signaling, Neurotrophin Signaling Pathway