IDH1 antibody (AA 198-414)

Catalog No. ABIN5027284

The Mouse Monoclonal anti-IDH1 antibody is suitable to detect IDH1 in samples from Human. It has been validated for IHC.

Quick Overview for IDH1 antibody (AA 198-414) (ABIN5027284)

Target: IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IDH1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: ABM44B3

Product Details anti-IDH1 Antibody

Binding Specificity: AA 198-414

Purification: Protein G Chromatography

Immunogen: A partial length recombinant IDH1 protein (amino acids 198-414) was used as the immunogen for this antibody

Isotype: IgG2a kappa

Application Details

Application Notes: IHC: 5 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for IDH1

Target: IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

Alternative Name: IDH1

Background: Isocitrate dehydrogenase 1 (IDH1) is a dimeric cytosolic NADP-dependent dehydrogenase that catalyzes decarboxylation of isocitrate into alpha-ketoglutarate. It belongs to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). It serves a significant role in cytoplasmic NADPH production. It is found in the cytoplasm and peroxisomes. IDH1 is of great importance in cell metabolism and energy conversion. Mutations in IDH1 are found in a somatic mosaic fashion in patients with multiple enchondromas.

Gene ID: 3417

UniProt: O75874

Pathways: Warburg Effect