IFIT2 antibody (AA 150-370)

Catalog No. ABIN5027290

Product Details anti-IFIT2 Antibody

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Binding Specificity: AA 150-370

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant IFIT2 protein (amino acids 150-370) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for IFIT2

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Alternative Name: IFIT2 (IFIT2 Products)

Synonyms: G10P2 antibody, GARG-39 antibody, IFI-54 antibody, IFI-54K antibody, IFI54 antibody, IFIT-2 antibody, ISG-54 K antibody, ISG-54K antibody, ISG54 antibody, P54 antibody, cig42 antibody, wu:fb58d07 antibody, DKFZp468G198 antibody, AV302338 antibody, Ifi54 antibody, interferon induced protein with tetratricopeptide repeats 2 antibody, interferon-induced protein with tetratricopeptide repeats 2 antibody, interferon-induced protein with tetratricopeptide repeats 15 antibody, IFIT2 antibody, Ifit2 antibody, ifit15 antibody

Background: Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) is one of four related human (ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, ISG58/IFIT5) and three related mouse proteins (Ifit1, Ifit2, Ifit3) characterized by tetratricopeptide motifs. IFIT2 interacts with eukaryotic initiation factor 3 (eIF3)e and eIF3c to inhibit translation. IFIT2 interacts with some AU-rich RNA regions, which seems to be associated with antiviral activity. IFIT2 possesses antiviral activity against corona virus and West Nile virus by acting on the capped viral mRNA and protects from lethal vesicular stomatitis virus neuropathogenesis. Besides the antiviral activity, IFIT2 expression was associated with induction of apoptosis. IFIT2 may alter proinflammatory cytokine response and therefore be involved in the development of septic shock.

Molecular Weight: 54 kDa

Gene ID: 3433

UniProt: P09913