JMJD5 antibody (AA 20-220)

Catalog No. ABIN5027324

Product Details anti-JMJD5 Antibody

Target: JMJD5 (Jumonji Domain Containing 5 (JMJD5))

Binding Specificity: AA 20-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JMJD5 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant JMJD5 protein (amino acids 20-220) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for JMJD5

Target: JMJD5 (Jumonji Domain Containing 5 (JMJD5))

Alternative Name: JMJD5 (JMJD5 Products)

Synonyms: jmjd5 antibody, JMJD5 antibody, 3110005O21Rik antibody, Jmjd5 antibody, zgc:173863 antibody, zgc:91962 antibody, RGD1304823 antibody, lysine demethylase 8 antibody, jumonji domain containing 5 antibody, hypothetical protein antibody, lysine (K)-specific demethylase 8 antibody, KDM8 antibody, PTRG_02386 antibody, MCYG_00400 antibody, CC1G_13927 antibody, PGTG_16928 antibody, kdm8 antibody, Kdm8 antibody

Background: JMJD5 (Jumonji domain-containing protein 5) or commonly called as Lysine-specific demethylase 8 is a histone lysine demethylase that specifically demethylates dimethylated Lys 36 of histone H3 (H3K36me2) thereby activating the target gene. JMJD5 is important for G2/M phase cell cycle progression. JMJD5 is also a potential tumor suppression protein. JMJD5 helps in regulation of cancer proliferation by regulating cyclin-A1. JMJD5 has three isoforms (47, 24, 50 kDa), all localized in nucleus. JMJD5 is weakly expressed in most normal cells but highly expressed in breast cancer cells.

Molecular Weight: 47 kDa

Gene ID: 79831

UniProt: Q8N371

Pathways: Chromatin Binding