MAFA antibody (AA 192-353)

Catalog No. ABIN5027344

The Rabbit Polyclonal anti-MAFA antibody is suitable to detect MAFA in samples from Human. It has been validated for WB.

Quick Overview for MAFA antibody (AA 192-353) (ABIN5027344)

Target: MAFA (Transcription Factor MafA (MAFA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAFA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAFA Antibody

Binding Specificity: AA 192-353

Purification: Protein A Chromatography

Immunogen: A partial length recombinant Mafa protein (amino acids 192-353) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for MAFA

Target: MAFA (Transcription Factor MafA (MAFA))

Alternative Name: Mafa

Background: Musculoaponeurotic fibrosarcoma oncogene family A (MafA) is a pancreatic transcriptional factor that is important to pancreatic beta-cell function. It is a member of the musculo-aponeurotic fibrosarcoma oncogene family, a subgroup of the basic leucine zipper transcription factors with homology to the v-Maf oncoprotein. It acts as a transcriptional regulator that promotes the expression of genes important in glucose-induced insulin secretion, such as insulin, glucokinase and glucose transporter protein-2. Mafa is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet beta-cells thus may be involved in pathogenesis of diabetes.

Molecular Weight: 36 kDa

Gene ID: 389692

UniProt: Q8NHW3

Pathways: Hormone Transport