MEIS1 antibody (AA 163-352)

Catalog No. ABIN5027352

Product Details anti-MEIS1 Antibody

Target: MEIS1 (Meis Homeobox 1 (MEIS1))

Binding Specificity: AA 163-352

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEIS1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant MEIS1 protein (amino acids 163-352) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for MEIS1

Target: MEIS1 (Meis Homeobox 1 (MEIS1))

Alternative Name: MEIS1 (MEIS1 Products)

Synonyms: meis antibody, 1323/07 antibody, 1422/04 antibody, CG17117 antibody, Dm-HTH antibody, Dmel\\CG17117 antibody, HTH antibody, Hth antibody, Meis1 antibody, P53 antibody, anon-EST:Liang-2.13 antibody, clone 2.13 antibody, dtl antibody, hth1 antibody, hth2 antibody, l(3)05745 antibody, l(3)86Ca antibody, cb224 antibody, id:ibd5078 antibody, meis1.1 antibody, wu:fb38b03 antibody, wu:fc02e11 antibody, wu:fd12a02 antibody, C530044H18Rik antibody, Evi8 antibody, Meis homeobox 1 antibody, Meis homeobox 1 S homeolog antibody, homothorax antibody, Meis homeobox 1 b antibody, MEIS1 antibody, meis1.S antibody, Meis1 antibody, hth antibody, meis1b antibody, meis1 antibody

Background: Myeloid ecotropoic viral insertion site 1 (MEIS1) is a transcription factor belonging to TALE (three amino acids loop extension) family. The gene for MEIS1 is mapped to human chromosome 2p15. The amino terminus contains binding domains for its interaction partners, the transcription factors HOXA9 and PBX1, followed by a homeobox DNA binding domain and carboxy-terminal transcriptional activation domains. It is expressed in hematopoietic stem and progenitor cells and increases during human megakaryocytic differentiation. MEIS1 plays a role in the normal development of the hematopoietic lineage and is over expressed in a subset of acute myeloid leukemias. Increased MEIS1 expression has also been observed in neuroblastomas and the expression level of the MEIS1 transcript is a prognostic indicator in breast cancer.

Molecular Weight: 43 kDa

Gene ID: 4211

UniProt: O00470

Pathways: Chromatin Binding