MAPKAP1 antibody (AA 250-522)

Catalog No. ABIN5027356

The Rabbit Polyclonal anti-MAPKAP1 antibody has been validated for WB. It is suitable to detect MAPKAP1 in samples from Human.

Quick Overview for MAPKAP1 antibody (AA 250-522) (ABIN5027356)

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKAP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAPKAP1 Antibody

Binding Specificity: AA 250-522

Purification: Protein A Chromatography

Immunogen: A partial length recombinant Mip1 protein (amino acids 250-522) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 1-3 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for MAPKAP1

Target: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Alternative Name: SAPK interacting proten 1/Mip1

Background: Stress-activated map kinase (SAPK )-interacting protein 1, also called as Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1), belongs to Stress-activated map kinase interacting protein 1 (SIN1) family. It is a subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors and also plays a critical role in AKT1 'Ser-473'phosphorylation. Except isoform 4 from its 6 isoforms , all can be incorporated into the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. It is ubiquitously expressed in heart and skeletal muscle. Diseases associated with MAPKAP1 include bronchiolitis obliterans organizing pneumonia and nephrogenic systemic fibrosis.

Molecular Weight: 50 kDa

Gene ID: 79109

UniProt: Q9BPZ7

Pathways: PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events