MUL1 antibody (AA 146-352)

Catalog No. ABIN5027374

The Mouse Monoclonal anti-MUL1 antibody is suitable to detect MUL1 in samples from Human. It has been validated for WB.

Quick Overview for MUL1 antibody (AA 146-352) (ABIN5027374)

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MUL1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ABM4F71

Product Details anti-MUL1 Antibody

Binding Specificity: AA 146-352

Purification: Protein G Chromatography

Immunogen: A partial length recombinant MUL1 protein (amino acids 146-352) was used as the immunogen for this antibody.

Isotype: IgG1

Application Details

Application Notes: WB: 4-8 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for MUL1

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Alternative Name: MUL1

Background: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase-1) is a crucial moderator of RIG-I (Retinoic Acid-Inducible-Gene-I) signaling. This protein is localized to the mitochondria where it interacts with MAVS (Mitochondrial Antiviral Signaling) and catalyzes RIG-I post-translational modifications that inhibit RIG-I-dependent cell signaling. MUL1 contains a unique BAM (Beside A Membrane) domain and a C-terminal RING-finger domain. This protein has been implicated in several processes that occur in animal cells such as NF-KappaB activation, innate immunity and antiviral signaling, suppression of PINK1/parkin defects, mitophagy in skeletal muscle, and caspase-dependent apoptosis.

Molecular Weight: 40 kDa

Gene ID: 79594

UniProt: Q969V5

Pathways: Positive Regulation of Endopeptidase Activity