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MUL1 antibody (AA 146-352)
MUL1
Reactivity: Human
WB
Host: Mouse
Monoclonal
ABM4F71
unconjugated
Product Details anti-MUL1 Antibody
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Target
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MUL1
(Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
Binding Specificity
All epitopes for MUL1 antibodies
AA 146-352
Reactivity
All reactivities for MUL1 antibodies
Human
Host
All hosts for MUL1 antibodies
Mouse
Clonality
All clonalities for MUL1 antibodies
Monoclonal
Conjugate
All conjugates for MUL1 antibodies
This MUL1 antibody is un-conjugated
Application
All applications for MUL1 antibodies
Western Blotting (WB)
Purification
Protein G Chromatography
Immunogen
A partial length recombinant MUL1 protein (amino acids 146-352) was used as the immunogen for this antibody.
Clone
ABM4F71
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
WB: 4-8 μg/mL
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Target Details for MUL1
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Target
MUL1
(Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
Alternative Name
MUL1 (MUL1 Products )
Synonyms
C1orf166 antibody, GIDE antibody, MAPL antibody, MULAN antibody, RNF218 antibody, RP11-401M16.2 antibody, mul1 antibody, zgc:92166 antibody, 0610009K11Rik antibody, AV000801 antibody, Gide antibody, RGD1309944 antibody, im:7146383 antibody, zgc:165594 antibody, mitochondrial E3 ubiquitin protein ligase 1 antibody, mitochondrial E3 ubiquitin protein ligase 1 L homeolog antibody, mitochondrial E3 ubiquitin protein ligase 1a antibody, mitochondrial ubiquitin ligase activator of NFKB 1 antibody, mitochondrial E3 ubiquitin protein ligase 1b antibody, MUL1 antibody, mul1.L antibody, mul1a antibody, Mul1 antibody, mul1b antibody
Background
MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase-1) is a crucial moderator of RIG-I (Retinoic Acid-Inducible-Gene-I) signaling. This protein is localized to the mitochondria where it interacts with MAVS (Mitochondrial Antiviral Signaling) and catalyzes RIG-I post-translational modifications that inhibit RIG-I-dependent cell signaling. MUL1 contains a unique BAM (Beside A Membrane) domain and a C-terminal RING-finger domain. This protein has been implicated in several processes that occur in animal cells such as NF-KappaB activation, innate immunity and antiviral signaling, suppression of PINK1/parkin defects, mitophagy in skeletal muscle, and caspase-dependent apoptosis.
Molecular Weight
40 kDa
Gene ID
79594
UniProt
Q969V5
Pathways
Positive Regulation of Endopeptidase Activity
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