NR2F6 antibody (AA 210-400)

Catalog No. ABIN5027402

The Rabbit Polyclonal anti-NR2F6 antibody (ABIN5027402) specifically detects NR2F6 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for NR2F6 antibody (AA 210-400) (ABIN5027402)

Target: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NR2F6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NR2F6 Antibody

Binding Specificity: AA 210-400

Purification: Protein A Chromatography

Immunogen: A partial length recombinant NR2F6 protein (amino acids 210-400) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL, IHC: 5 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for NR2F6

Target: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Alternative Name: NR2F6

Background: NR2F6 (Nuclear receptor subfamily 2 group F member 6) is a nuclear zinc-finger orphan receptor which acts as a critical PKC (protein kinase C) substrate and essential regulator of CD4(+) T cell activation responses. It Inhibits NFATC (Nuclear factor of activated T-cells) transcription factor DNA binding and subsequently its transcriptional activity. It acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. It is involved in development of forebrain circadian clock.

Molecular Weight: 45 kDa

Gene ID: 2063

UniProt: P10588

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Photoperiodism