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SPARC antibody (AA 52-268)
SPARC
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SPARC Antibody
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Target
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SPARC
(Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))
Binding Specificity
All epitopes for SPARC antibodies
AA 52-268
Reactivity
All reactivities for SPARC antibodies
Human
Host
All hosts for SPARC antibodies
Rabbit
Clonality
All clonalities for SPARC antibodies
Polyclonal
Conjugate
All conjugates for SPARC antibodies
This SPARC antibody is un-conjugated
Application
All applications for SPARC antibodies
Western Blotting (WB)
Purification
Protein A Chromatography
Immunogen
A partial length recombinant SPARC/Osteonectin protein (amino acids 52-268) was used as the immunogen for this antibody.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
WB: 2-4 μg/mL
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Target Details for SPARC
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Target
SPARC
(Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))
Alternative Name
SPARC/Osteonectin (SPARC Products )
Synonyms
ON antibody, AA517111 antibody, BM-40 antibody, hm:zeh0062 antibody, SPARC antibody, sparc antibody, secreted protein acidic and cysteine rich antibody, secreted acidic cysteine rich glycoprotein antibody, secreted protein, acidic, cysteine-rich (osteonectin) antibody, secreted protein, acidic, cysteine-rich (osteonectin) L homeolog antibody, secreted protein, acidic, cysteine-rich (osteonectin) S homeolog antibody, SPARC antibody, Sparc antibody, sparc antibody, sparc.L antibody, sparc.S antibody
Background
SPARC (Secreted protein, acidic, cysteine-rich) is a glycoprotein that binds to collagen type I and other proteins in the extracellular matrix. It is involved in normal tissue remodeling as it regulates the deposition of extracellular matrix, and also plays a role in neoplastic transformation. It modulates interactions between tumoral cells and the peri-tumoral stroma. Homozygous mutations in SPARC give rise to severe bone fragility in humans. SPARC negatively regulates glucose metabolism in hepatocellular carcinoma (HCC). Overexpression of SPARC inhibited glucose uptake and lactate product through downregulation of key enzymes of glucose metabolism.
Molecular Weight
35 kDa
Gene ID
6678
UniProt
P09486
Pathways
Autophagy
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