TRBP antibody (AA 150-366)

Catalog No. ABIN5027591

Product Details anti-TRBP Antibody

Target: TRBP (TARBP2P) (TAR (HIV-1) RNA Binding Protein 2 Pseudogene (TARBP2P))

Binding Specificity: AA 150-366

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRBP antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A Chromatography

Immunogen: A partial length recombinant TRBP protein (amino acids 150-366) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 6-7 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for TRBP

Target: TRBP (TARBP2P) (TAR (HIV-1) RNA Binding Protein 2 Pseudogene (TARBP2P))

Alternative Name: TRBP (TARBP2P Products)

Synonyms: TRBP antibody, TARBP2P1, RISC loading complex RNA binding subunit pseudogene 1 antibody, TARBP2P1 antibody

Background: TRBP, also known as TARBP2 (TAR (HIV-1) RNA binding protein 2) is a contributory agent of acquired immunodeficiency syndrome (AIDS). TRBP binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. It also plays a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 and promotes translation of TAR-containing RNAs independently of EIF2AK2/PKR. Diseases associated with TARBP2 include acquired immunodeficiency syndrome. TARBP2 is highly expressed in adipose tissue, adrenal cortex, adrenal gland, amniotic fluid and amygdala. TRBP exists in two isoforms whereas alternate splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.

Molecular Weight: 48 KDa

Gene ID: 6895

UniProt: Q15633

Pathways: Regulatory RNA Pathways, Ribonucleoprotein Complex Subunit Organization