CRLF2 antibody (AA 97-252)

Catalog No. ABIN5027605

The Mouse Monoclonal anti-CRLF2 antibody is suitable to detect CRLF2 in samples from Human. It has been validated for WB.

Quick Overview for CRLF2 antibody (AA 97-252) (ABIN5027605)

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CRLF2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ABM28B6

Product Details anti-CRLF2 Antibody

Binding Specificity: AA 97-252

Purification: Protein G Chromatography

Immunogen: A partial length recombinant TSLPR protein (amino acids 97-252) was used as the immunogen for this antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for CRLF2

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Alternative Name: TSLP Receptor

Background: TSLPR (thymic stromal lymphopoietin receptor) also known as CRLF2 (cytokine receptor-like factor 2) is a member of type I cytokine receptor. It binds its ligand TSLP (thymic stromal lymphopoietin) as a heterodimer with IL7R. TSLP ligand is produced by epithelial cells in order to activate dendritic cells, and is involved in inflammation, allergic responses as well as B-cell precursor proliferation and survival. The interaction between TSLP and its heterodimeric receptor activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. High expression of CRLF2 is associated with a poor prognosis in adult and high-risk pediatric cases of B-ALL (B-cell acute lymphoblastic leukemias).

Molecular Weight: 42 kDa

Gene ID: 64109

UniProt: Q9HC73