TXNIP antibody (AA 50-300)

Catalog No. ABIN5027615

This anti-TXNIP antibody is a Rabbit Polyclonal antibody detecting TXNIP in WB. Suitable for Human.

Quick Overview for TXNIP antibody (AA 50-300) (ABIN5027615)

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNIP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TXNIP Antibody

Binding Specificity: AA 50-300

Purification: Protein A Chromatography

Immunogen: A partial length recombinant TxNIP protein (amino acids 50-300) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 1-3 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Alternative Name: TxNIP/VDUP1

Background: TXNIP (thioredoxin interacting protein) inhibits thioredoxin activity by limiting its bioavailability in response to oxidative stress. TXNIP restores COPS5-induced suppression of CDKN1B stability by interacting with COPS5 and blocks the COPS5-mediated translocation of CDKN1B from nucleus to the cytoplasm. TXNIP functions as a transcriptional repressor. TXNIP has been reported to be a suppressor of tumor cell growth and inhibits the proteasomal degradation of DDIT4, contributing to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). TXNIP is expresed in adipose tissue, adrenal cortex, adrenal gland, amniotic fluid and amygdale.

Molecular Weight: 44 kDa

Gene ID: 10628

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome