CCR6 antibody

Catalog No. ABIN5027745

This Rat Monoclonal antibody specifically detects CCR6 in WB. It exhibits reactivity toward Mouse.

Quick Overview for CCR6 antibody (ABIN5027745)

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CCR6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ABM40H1

Product Details anti-CCR6 Antibody

Purification: Protein G Chromatography

Immunogen: Full length recombinant protein from mCD196 was used as the immunogen for this antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for CCR6

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Alternative Name: mCD196

Background: CD196 displays a high degree of genetic homology between mouse and human. Moreover, in both species it is chromosomally segregated from the main chemokine receptor gene cluster. mCD196 is expressed by myeloid DCs (dendritic cells), mature B cells, subpopulations of memory/effector CD4+ and CD8+ T cells, but not plasmacytoid DCs or naï,ve T cells. mCD196 mediates their migration and function via stimulation with its ligand CCL20 (also known as macrophage inflammatory protein (MIP)-3alpha. mCD196 expression has been correlated with stage and prognosis in a variety of cancers including hepatocellular carcinoma, colorectal carcinoma, glioma, and non-small cell lung cancer. It is also believed to play a role in regulation of cancer progression.

Molecular Weight: 47 kDa

Gene ID: 1235

UniProt: P51684

Pathways: cAMP Metabolic Process