Nibrin antibody (AA 350-400)

Catalog No. ABIN504727

This Rabbit Polyclonal antibody specifically detects Nibrin in WB and IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for Nibrin antibody (AA 350-400) (ABIN504727)

Target: Nibrin (NBN)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nibrin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Nibrin Antibody

Binding Specificity: AA 350-400

Cross-Reactivity: Human, Mouse (Murine)

Purification: affinity purified

Immunogen: Synthetic peptide made to an internal portion of the mouse protein (within AA 350-400). [Swiss-Prot# Q9R207].

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for Nibrin

Target: Nibrin (NBN)

Alternative Name: p95/NBS1

Background: The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.

UniProt: Q9R207

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response