HLA-ABC antibody (FITC)

Catalog No. ABIN5067847

This Mouse Monoclonal antibody specifically detects HLA-ABC in FACS. It exhibits reactivity toward Human, Baboon, Cynomolgus and Rhesus Monkey.

Quick Overview for HLA-ABC antibody (FITC) (ABIN5067847)

Target: HLA-ABC

Reactivity: Human, Baboon, Cynomolgus, Rhesus Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This HLA-ABC antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: W6-32

Product Details anti-HLA-ABC Antibody (FITC)

Purpose: Anti-HLA-ABC FITC Antibody

Characteristics: Clone W6/32 recognizes a cell surface 45 kD non-polymorphic epitope protein shared among products of the HLA-A, B, and C loci. HLA class I antigen associated with beta 2-microglobulin are expressed by all human nucleated cells and HLA-Class I down regulation occurs frequently in many cancers which might adversely affect the clinical course of cancer and the outcome of T-cell-based immunotherapy. HLA-Class I present specific foreign antigen to CD8+ T cells which play central role against infection, tumor and also generation of autoimmune diseases.

Purification: Purified

Purity: >95 %

Immunogen: Human Leukocytes

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for HLA-ABC

Target: HLA-ABC

Alternative Name: HLA-ABC

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints