AADAC
Reactivity: Human
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Buffer
In 1x PBS, pH 7.4
Handling Advice
Aliquot to avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Muta, Fukami, Nakajima, Yokoi: "N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity." in: Biochemical pharmacology, Vol. 87, Issue 2, pp. 352-9, (2014) (PubMed).
Kobayashi, Fukami, Nakajima, Watanabe, Nakajima, Yokoi: "Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, Issue 4, pp. 671-9, (2012) (PubMed).
Shimizu, Fukami, Kobayashi, Takamiya, Aoki, Nakajima, Yokoi: "A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, Issue 6, pp. 1183-90, (2012) (PubMed).
Kobayashi, Fukami, Higuchi, Nakajima, Yokoi: "Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia." in: Biochemical pharmacology, Vol. 84, Issue 9, pp. 1196-206, (2012) (PubMed).
Watanabe, Fukami, Nakajima, Takamiya, Aoki, Yokoi: "Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 37, Issue 7, pp. 1513-20, (2009) (PubMed).