AKR1C2 antibody (AA 224-323)

Catalog No. ABIN514927

This Mouse Monoclonal antibody specifically detects AKR1C2 in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for AKR1C2 antibody (AA 224-323) (ABIN514927)

Target: AKR1C2 (Aldo-keto Reductase Family 1, Member C2 (AKR1C2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AKR1C2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 3C11

Product Details anti-AKR1C2 Antibody

Binding Specificity: AA 224-323

Purpose: Mouse monoclonal antibody raised against a partial recombinant AKR1C2.

Sequence: EEPWVDPNSP VLLEDPVLCA LAKKHKRTPA LIALRYQLQR GVVVLAKSYN EQRIRQNVQV FEFQLTSEEM KAIDGLNRNV RYLTLDIFAG PPNYPVSDEY

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: AKR1C2 (AAH63574, 224 a.a. ~ 323 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-AKR1C2 antibody (ABIN514927)

Hevir, Vouk, Sinkovec, Ribi?-Pucelj, Rižner: "Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis." in: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 217-26, (2011) (PubMed).

Takahashi, Bains, Pfeifer, Grigliatti, Reid, Riggs: "Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 36, Issue 6, pp. 991-4, (2008) (PubMed).

Target Details for AKR1C2

Target: AKR1C2 (Aldo-keto Reductase Family 1, Member C2 (AKR1C2))

Alternative Name: AKR1C2

Background: Full Gene Name: aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2, bile acid binding protein, 3-alpha hydroxysteroid dehydrogenase, type III)
Synonyms: AKR1C-pseudo,BABP,DD,DD2,DDH2,HAKRD,HBAB,MCDR2

Gene ID: 1646

Pathways: Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process