UGCG antibody (AA 33-131)

Catalog No. ABIN521242

This Mouse Monoclonal antibody specifically detects UGCG in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for UGCG antibody (AA 33-131) (ABIN521242)

Target: UGCG (UDP-Glucose Ceramide Glucosyltransferase (UGCG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This UGCG antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1E5

Product Details anti-UGCG Antibody

Binding Specificity: AA 33-131

Purpose: Mouse monoclonal antibody raised against a partial recombinant UGCG.

Sequence: TRLHLNKKAT DKQPYSKLPG VSLLKPLKGV DPNLINNLET FFELDYPKYE VLLCVQDHDD PAIDVCKKLL GKYPNVDARL FIGGKKVGIN PKINNLMPG

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: UGCG (NP_003349, 33 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-UGCG antibody (ABIN521242)

Shibina, Seidel, Somanchi, Lee, Stermann, Maurer, Lode, Reynolds, Huebener: "Fenretinide sensitizes multidrug-resistant human neuroblastoma cells to antibody-independent and ch14.18-mediated NK cell cytotoxicity." in: Journal of molecular medicine (Berlin, Germany), Vol. 91, Issue 4, pp. 459-72, (2013) (PubMed).

Haynes, Filippov, Filippova, Yang, Zhang, Duerksen-Hughes: "DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells." in: Biochimica et biophysica acta, Vol. 1821, Issue 7, pp. 943-53, (2012) (PubMed).

Target Details for UGCG

Target: UGCG (UDP-Glucose Ceramide Glucosyltransferase (UGCG))

Alternative Name: UGCG

Background: Full Gene Name: UDP-glucose ceramide glucosyltransferase
Synonyms: GCS

Gene ID: 7357

NCBI Accession: NM_003358