RNF8 antibody (AA 1-485)

Catalog No. ABIN522468

This anti-RNF8 antibody is a Mouse Polyclonal antibody detecting RNF8 in WB and IF. Suitable for Human. This Primary Antibody has been cited in 4+ publications.

Quick Overview for RNF8 antibody (AA 1-485) (ABIN522468)

Target: RNF8 (Ring Finger Protein 8 (RNF8))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This RNF8 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-RNF8 Antibody

Binding Specificity: AA 1-485

Purpose: Mouse polyclonal antibody raised against a full-length human RNF8 protein.

Sequence: MGEPGFFVTG DRAGGRSWCL RRVGMSAGWL LLEDGCEVTV GRGFGVTYQL VSKICPLMIS RNHCVLKQNP EGQWTIMDNK SLNGVWLNRA RLEPLRVYSI HQGDYIQLGV PLENKENAEY EYEVTEEDWE TIYPCLSPKN DQMIEKNKEL RTKRKFSLDE LAGPGAEGPS NLKSKINKVS CESGQPVKSQ GKGEVASTPS DNLDPKLTAL EPSKTTGAPI YPGFPKVTEV HHEQKASNSS ASQRSLQMFK VTMSRILRLK IQMQEKHEAV MNVKKQTQKG NSKKVVQMEQ ELQDLQSQLC AEQAQQQARV EQLEKTFQEE EQHLQGLEIA QGEKDLKQQL AQALQEHWAL MEELNRSKKD FEAIIQAKNK ELEQTKEEKE KMQAQKEEVL SHMNDVLENE LQCIICSEYF IEAVTLNCAH SFCSYCINEW MKRKIECPIC RKDIKSKTYS LVLDNCINKM VNNLSSEVKE RRIVLIRERK AKRLF

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: RNF8 (NP_003949.1, 1 a.a. ~ 485 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-RNF8 antibody (ABIN522468)

Hodge, Ismail, Edwards, Hura, Xiao, Tainer, Hendzel, Glover: "RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment." in: The Journal of biological chemistry, Vol. 291, Issue 18, pp. 9396-410, (2016) (PubMed).

Yang, Deng, Hau, Liu, Lau, Cheung, Huen, Tsao: "Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 95, Issue 8, pp. 937-50, (2015) (PubMed).

Hau, Deng, Jia, Yang, Tsurumi, Chiang, Huen, Tsao: "Role of ATM in the formation of the replication compartment during lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells." in: Journal of virology, Vol. 89, Issue 1, pp. 652-68, (2014) (PubMed).

Morris, Boutell, Keppler, Densham, Weekes, Alamshah, Butler, Galanty, Pangon, Kiuchi, Ng, Solomon: "The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress." in: Nature, Vol. 462, Issue 7275, pp. 886-90, (2009) (PubMed).

Target Details for RNF8

Target: RNF8 (Ring Finger Protein 8 (RNF8))

Alternative Name: RNF8

Background: Full Gene Name: ring finger protein 8
Synonyms: FLJ12013,KIAA0646

Gene ID: 9025

NCBI Accession: NM_003958

Pathways: Production of Molecular Mediator of Immune Response