CRBA1 antibody (C-Term)

Catalog No. ABIN5514391

The Rabbit Polyclonal anti-CRBA1 antibody is suitable to detect CRBA1 in samples from Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for CRBA1 antibody (C-Term) (ABIN5514391)

Target: CRBA1 (beta-Crystallin a3 (CRBA1))

Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Product Details anti-CRBA1 Antibody

Binding Specificity: C-Term

Sequence: SGAWVCYQYP GYRGYQYILE CDHHGGDYKH WREWGSHAQT SQIQSIRRIQ

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Characteristics: This is a rabbit polyclonal antibody against CRBA1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CRBA1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CRBA1

Target: CRBA1 (beta-Crystallin a3 (CRBA1))

Alternative Name: CRBA1

Background: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'.

Alias Symbols: CRYBA1, CRYB1,

Protein Interaction Partner: RHOXF2, RBPMS, CRYBB3, CRYBB1, CRYBA1, CRYAB, CRYAA,

Protein Size: 215

Gene ID: 1411

NCBI Accession: NP_005199

UniProt: P05813