RNASEH2B antibody (C-Term)

Catalog No. ABIN5514417

This Rabbit Polyclonal antibody specifically detects RNASEH2B in WB. It exhibits reactivity toward Human.

Quick Overview for RNASEH2B antibody (C-Term) (ABIN5514417)

Target: RNASEH2B (Ribonuclease H2, Subunit B (RNASEH2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASEH2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RNASEH2B Antibody

Binding Specificity: C-Term

Purpose: RNASEH2B Antibody - C-terminal region

Sequence: SKYLKLPEPS ASLPNPPSKK IKLSDEPVEA KEDYTKFNTK DLKTEKKNSK

Characteristics: This is a rabbit polyclonal antibody against RNH2B. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RNH2B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75764-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for RNASEH2B

Target: RNASEH2B (Ribonuclease H2, Subunit B (RNASEH2B))

Alternative Name: RNASEH2B

Background:

Background Information: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).

Gene Name: ribonuclease H2 subunit B

Alternative Symbols: AGS2, DLEU8

Protein Name: ribonuclease H2 subunit B

Molecular Weight: 34kDa

Gene ID: 79621

NCBI Accession: NP_078846

UniProt: Q5TBB1