RNASEH2B antibody (C-Term)

Catalog No. ABIN5514417

Product Details anti-RNASEH2B Antibody

Target: RNASEH2B (Ribonuclease H2, Subunit B (RNASEH2B))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNASEH2B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: SKYLKLPEPS ASLPNPPSKK IKLSDEPVEA KEDYTKFNTK DLKTEKKNSK

Characteristics: This is a rabbit polyclonal antibody against RNH2B. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RNH2B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RNASEH2B

Target: RNASEH2B (Ribonuclease H2, Subunit B (RNASEH2B))

Alternative Name: RNH2B (RNASEH2B Products)

Synonyms: AGS2 antibody, DLEU8 antibody, 1110019N06Rik antibody, 2610207P08Rik antibody, Dleu8 antibody, ribonuclease H2 subunit B antibody, ribonuclease H2, subunit B antibody, ribonuclease H2 subunit B L homeolog antibody, RNASEH2B antibody, Rnaseh2b antibody, rnaseh2b.L antibody

Background: RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).

Alias Symbols: RNASEH2B, DLEU8,

Protein Interaction Partner: UBC, ANP32E, UBQLN2, RDX, DNAJB1, RNASEH2C, RNASEH2A, NRAS,

Protein Size: 312

Gene ID: 79621

NCBI Accession: NP_078846

UniProt: Q5TBB1